Furoin is a useful chemical compound with a variety of research applications. We are pleased to offer high quality Furoin in various sizes (for research, pilot-scale, or production applications) from milligrams to multi-kilogram batches, making it easy for you to choose the right amount to suit your needs.
General description and preparation:
Furoin or 1,2-di(furan-2-yl)-2-hydroxyethanone [552-86-3]
is a white crystalline solid with the melting point of 136-137 °C.
It can be produced from furfural via benzoin condensation in presence of cyanide ion
or N-heterocyclic carbene catalyst as various thiazolium and imidazolium ions.
They can be further supported as a recyclable precatalysts, which upon treatment with a base, catalyze furfural self-condensation coupling reaction into furoin.
Furoin synthesis from furfural is also catalyzed by vitamin B1 (thiamine). In 1957, Ronald Breslow proposed the mechanism of reaction that involves a relatively stable carbene form of thiamine, which was the first evidence for the existence of persistent carbenes.
Application of Furoin:
Furoin can be used in synthesis of pyrazine and quanoxiline derivatives by condensation with diamines.
Different tetrasubstituted pyroles can be prepared from furoin as α-hydroxy ketone via a base-promoted three-component reaction with malononitrile and alcohols
or 1,3-dicarbonyls and ammonium acetate.
Product categorization (Chemical groups):
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