Research on Chemicals and Custom Synthesis

The Georganics research department is actively engaged in organic chemistry research at an academic/university level. Our interest lies in fundamental research on new reaction cascades involving C-H activation/carbonylation, total syntheses of natural products, and flow chemistry.

Flow chemistry is utilized in the synthesis of natural products and in the optimisation of various reaction steps in the preparation of a range of different products.

The active participation of our research group members in problem solving current research challenges ensures that our knowledge expands for our custom synthesis/research programs or our customers.

Research on Chemicals and Custom Synthesis

Flow Pd(II)-Catalysed Carbonylative Cyclisation in the Total Synthesis of Jaspine B

Recent Applications of Continuous Flow in Homogeneous Palladium Catalysis

A Short Asymmetric Synthesis of Sauropunols A–D

Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source

Recent advances in the construction of isoindolo[2,1-a]indol/indolin-6-ones via C-C cross-coupling reactions

One-Step Synthesis of Isoindolo[2,1-a]indol-6-ones via Tandem Pd-Catalyzed Aminocarbonylation and C–H Activation

Glyoxylic Acid as a Carbon Monoxide Source for Carbonylation Reactions

Zn-Mediated Reduction of Oxalyl Chloride Forming CO and Its Application in Carbonylation Reactions

Palladium-catalysed cyclisation of alkenols: Synthesis of oxaheterocycles as core intermediates of natural compounds

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube-in-Tube Gas-Liquid Microreactors.

Asymmetric Formal Synthesis of (+)-Pyrenolide D

Continuous-Flow Processing of Gaseous Ammonia Using a Teflon AF-2400 Tube-in-Tube Reactor: Synthesis of Thioureas and In-Line Titrations.

A total synthesis of the ammonium ionophore, (–)-enniatin B

Continuous stream processing: a prototype magnetic field induced flow mixer

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

Syngas Mediated C-C Bond Formation in Flow: Selective Rhodium-Catalyzed Hydroformylation of Styrenes.

The Continuous-Flow Synthesis of Styrenes using Ethylene in a Palladium Catalysed Heck Cross-Coupling Reaction.

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

A Universal Strategy for Synthesis of Agropyrenol Family. Total Synthesis of Agropyrenol, Sordarial, and Heterocornol A and B

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