Continuous-Flow Processing of Gaseous Ammonia Using a Teflon AF-2400 Tube-in-Tube Reactor: Synthesis of Thioureas and In-Line Titrations.

Duncan L. Browne, Matthew O'Brien, Peter Koos, Philippa B. Cranwell, Anastasios Polyzos and Steven V. LeySynlett 2012; 23(9): 1402-1406Publication Date: Jan 1, 2012

A simple tube-in-tube reactor based on the gas-permeable membrane Teflon AF-2400 was used in the continuous flow reaction of gaseous ammonia with isothiocyanates and one isocyanate. A colourimetric in-line titration technique is also reported as a simple method to quantify the amount of ammonia taken up by the solvent in the system.