Chemical glossary page iconDennis X. Hu, Max Bielitza, Peter Koos and Steven V. LeyTetrahedron Lett. 2012, 53, 4077-4079Publication Date: 08 August 2012

A nine-step (longest linear) batch total synthesis of the cyclic hexadepsipeptide (–)-enniatin B is described. The synthesis minimizes precipitation during reaction conditions for adaptability to flow synthesis. The route was used to prepare >100 mg of the natural product.

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