Methyl 6-aminonicotinate

Methyl 6-aminonicotinate [36052-24-1] or methyl 6-aminopyridine-3-carboxylate is white crystalline solid with the melting point of 154-156 °C.^[1] It is a methyl ester of aminonicotinic acid.

Preparation of Methyl 6-aminonicotinate:

It can be easily prepared from 6-aminonicotinic acid by reaction with aqueous hydrogen chloride in methanol under reflux.^[2]

Application:

Methyl 6-aminonicotinate is useful and versatile building block in the synthesis of various important pyridine derivatives. It was used in the synthesis of histone deacetylase 3 (HDAC3) selective inhibitors targeting breast cancer stem cells.^[3] Methyl 6-aminonicotinate served as a substrate in the synthesis of glucokinase activators which may represent a new approach to diabetes therapy.^[4]

Product categorization (Chemical groups):

Main category:

• Amines / Amine salts / Imines
• Carboxylic acid esters / Lactones

Second level:

• Aromatic compounds

Third level:

• Pyridine derivatives

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