L-Pyroglutamic acid is a useful chemical compound with a variety of research applications. We are pleased to offer high quality L-Pyroglutamic acid in various sizes (for research, pilot-scale, or production applications) from milligrams to multi-kilogram batches, making it easy for you to choose the right amount to suit your needs.
L-Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid) [98-79-3]
is a five-membered lactam of glutamic acid. It is a pale yellow crystalline solid with the melting point of 155-157 °C.
It is a ubiquitous, but little studied natural amino acid derivative. It occurs naturally in fruits, some plant foods, dairy, and fermented products such as soy sauce. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase.
Preparation of L-pyroglutamic acid:
PCA can be easily obtained by direct thermal dehydration of L-glutamic acid in water under reflux.
Application of L-pyroglutamic acid:
In neurology, the brain-boosting effects of PCA were discovered in 1984. It plays an important role in the preservation and activity of the key neurotransmitters acetylcholine, gamma-aminobutyric acid (GABA) and glutamic acid.
It readily passes the blood-brain barrier to stimulate cognitive-enhancing function in rats
and reduce age-associated memory decline in humans.
In drug delivery, PCA esters can be used as dermal penetration enhancers for therapeutic agents having poor skin permeation or hair growth agents.
In chemical synthesis, it has been used as a versatile chiral building block in asymmetric synthesis of alkaloids, pharmaceuticals, and many other natural products.
PCA is also known as a novel organic nonlinear optical (NLO) material for tunable UV harmonic generation down to 266 nm at room temperature.
Product categorization (Chemical groups):
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