Zoledronic Acid – CAS# 165800-06-6 – Application

Zoledronic Acid, also known by its CAS number [165800-06-6], is a synthetic compound belonging to the third generation of bisphosphonates. It is similar in structure to pyrophosphate and works to prevent bone loss. Zoledronic Acid binds to hydroxyapatite crystals in the bone, slowing down their breakdown and stopping these crystals from forming and clumping together.^[1]

Application

Zoledronic Acid Accord contains the active substance zoledronic acid and is a ‘generic medicine’. This means that Zoledronic Acid Accord contains the same active substance and works in the same way as a ‘reference medicine’ already authorised in the European Union (EU) called Zometa.^[2]
Zoledronic Acid is an advanced synthetic medication designed to effectively inhibit bone resorption. By binding to bone minerals, it plays a crucial role in preventing osteoclast-mediated bone breakdown, thereby promoting better bone health. This powerful drug is clinically utilized for several important conditions, including:

• Osteoporosis, which weakens bones and increases the risk of fractures
• Hypercalcemia of malignancy, a serious condition characterized by elevated calcium levels due to cancer
• Bone metastases from cancer, where cancer spreads to the bones, leading to pain and other complications
• Paget’s disease of bone, a chronic disorder that can result in enlarged and deformed bones

Zoledronic Acid stands out for its powerful effects and long-lasting action, making it a top choice among modern bisphosphonates. One of its biggest advantages is that it only needs to be given once a year as an intravenous infusion. This simple and convenient dosing schedule helps patients stick to their treatment plan and reduces the need for frequent doctor visits. Patients benefit from fewer treatments, and doctors appreciate how well it works over time.

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