February 15, 2024Furan-3-methanol – preparation and application
Furan-3-methanol [4412-91-3] or 3-(Hydroxymethyl)furan is a colorless to yellow liquid with the boiling point of 79-80 °C/17 mmHg.[1] It is flammable liquid and its vapour and it can cause skin, eye and respiratory irritation.
Preparation of Furan-3-methanol:
Furan-3-methanol can be easily obtained by the reduction of appropriate furoic aldehyde[2], acid[3] and ester[4].
Application:
It is commonly used in various industries, including pharmaceuticals, resins, and coatings. Furan-3-methanol possesses unique properties, such as its ability to polymerize and form cross-linked networks, making it an essential component in the production of thermosetting resins. Additionally, it is utilized as a solvent and a flavoring agent in food and beverages.
It is useful building block in organic synthesis. Furan derivative is an imperative class of heterocyclic compound that has important biological properties. For example, it was used as a starting material for the synthesis of camptothecin and its derivatives[2], various sasquiterpenes[5] and pyridazinones with biological activity[6].
Product categorization (Chemical groups):
Main category:
Second level:
Third level:
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[2] P. Xu, D.S. Chen, J. Xi, Z. J. Yao Chem. Asian J. 2014, 10 (4), 976. doi:10.1002/asia.201403190
[3] A. Nitti, G. Bianchi, R. Po, T. M. Swanger, D. Pasini J. Am. Chem. Soc. 2017, 139 (26), 8788. doi:10.1021/jacs.7b03412
[4] T. Costas, M. C. Costas-Lago, N. Vila, P. Besada, E. Cano, C. Terán Eur. J. Med. Chem. 2015, 94, 113. doi:10.1016/j.ejmech.2015.02.061
[5] I. W. Mudianta, V. L. Challinor, A. E. Winters, K. L. Cheney, J. J. De Voss, M. J. Garson Beilstein J. Org. Chem. 2013, 9, 2925. doi:org/10.3762/bjoc.9.329
[6] T. Costas, M. C. Costas-Lago, N. Vila, P. Besada, E. Cano, C. Terán Eur. J. Med. Chem. 2015, 94, 113. doi:10.1016/j.ejmech.2015.02.061