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Furan-3-methanol

CAS#[4412-91-3]
G-codeGEO-01444
EC number224-570-7
Molecular formulaC5H6O2
Molecular weight98.1
Synonyms 3-(Hydroxymethyl)furan ; 3-Furanmethanol ; 3-Furancarbinol ; 3-Furfuryl alcohol ; 3-Furylcarbinol
Structure of Furan-3-methanol

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Specification

Appearanceclear colourless to faintly yellow liquid
Purity99,1% (GC)
Identification1H NMR conforms to structure

Structural identification

CAS#[4412-91-3]
G-codeGEO-01444
EC number224-570-7
SMILESOCC1=COC=C1
InChIInChI=1S/C5H6O2/c6-3-5-1-2-7-4-5/h1-2,4,6H,3H2
InChI KeyInChIKey=STJIISDMSMJQQK-UHFFFAOYSA-N
Download structure as .mol

Regulatory Information

Transport InformationALCOHOLS, FLAMMABLE, TOXIC, N.O.S. UN1986 3 (6.1)/ PG III
GHS pictogram
GHS02_flammableGHS07_harmful
Signal WordWarning
Hazard Statements
H226 - H302 - H312 - H332

H226 – Flammable liquid and vapour
H302 – Harmful if swallowed
H312 – Harmful in contact with skin
H332 – Harmful if inhaled

Precautionary Statements
P210 - P261 - P280 - P301+312 - P302+352 - P304+340 - P305+351+338

P210 – Keep away from heat/sparks/open flames/hot surfaces – No smoking:
P261 – Avoid breathing dust/fume/gas/mist/vapours/spray:
P280 – Wear protective gloves/protective clothing/eye protection/face protection:
P301+312 – IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P302+352 – IF ON SKIN: Wash with soap and water
P304+340 – IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P305+351+338 – IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing

Product categorization

Description

Show full description
Furan-3-methanol [4412-91-3] or 3-(Hydroxymethyl)furan is a colorless to yellow liquid with the boiling point of 79-80 °C/17 mmHg.[1] It is flammable liquid and its vapour and it can cause skin, eye and respiratory irritation.

Preparation of Furan-3-methanol:

Furan-3-methanol can be easily obtained by the reduction of appropriate furoic aldehyde[2], acid[3] and ester[4].

Application:

It is commonly used in various industries, including pharmaceuticals, resins, and coatings. Furan-3-methanol possesses unique properties, such as its ability to polymerize and form cross-linked networks, making it an essential component in the production of thermosetting resins. Additionally, it is utilized as a solvent and a flavoring agent in food and beverages. It is useful building block in organic synthesis. Furan derivative is an imperative class of heterocyclic compound that has important biological properties. For example, it was used as a starting material for the synthesis of camptothecin and its derivatives[2], various sasquiterpenes[5] and pyridazinones with biological activity[6].

Product categorization (Chemical groups):

Main category: Second level: Third level: _______________________________________________________________________
[1] E. Sherman, E. D. Amstutz  J. Am. Chem. Soc. 1950, 72 (5), 2195. doi:10.1021/ja01161a090 [2] P. Xu, D.S. Chen, J. Xi, Z. J. Yao Chem. Asian J. 2014, 10 (4), 976. doi:10.1002/asia.201403190 [3] A. Nitti, G. Bianchi, R. Po, T. M. Swanger, D. Pasini J. Am. Chem. Soc. 2017, 139 (26), 8788. doi:10.1021/jacs.7b03412 [4] T. Costas, M. C. Costas-Lago, N. Vila, P. Besada, E. Cano, C. Terán    Eur. J. Med. Chem. 2015, 94, 113. doi:10.1016/j.ejmech.2015.02.061 [5] I. W. Mudianta, V. L. Challinor, A. E. Winters, K. L. Cheney, J. J. De Voss, M. J. Garson Beilstein J. Org. Chem. 2013, 9, 2925. doi:org/10.3762/bjoc.9.329 [6] T. Costas, M. C. Costas-Lago, N. Vila, P. Besada, E. Cano, C. Terán Eur. J. Med. Chem. 2015, 94, 113. doi:10.1016/j.ejmech.2015.02.061

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