{"id":33842,"date":"2025-06-17T11:00:53","date_gmt":"2025-06-17T09:00:53","guid":{"rendered":"https:\/\/georganics.sk\/research\/flow-pdii-catalysed-carbonylative-cyclisation-in-the-total-synthesis-of-jaspine-b\/"},"modified":"2025-07-01T16:03:20","modified_gmt":"2025-07-01T14:03:20","slug":"flow-pdii-catalysed-carbonylative-cyclisation-in-the-total-synthesis-of-jaspine-b","status":"publish","type":"page","link":"https:\/\/georganics.sk\/fr\/research\/flow-pdii-catalysed-carbonylative-cyclisation-in-the-total-synthesis-of-jaspine-b\/","title":{"rendered":"Flow Pd(II)-Catalysed Carbonylative Cyclisation in the Total Synthesis of Jaspine B"},"content":{"rendered":"<div class=\"art-abstract in-tab hypothesis_container ai-optimize-introduction\">Ce travail d\u00e9crit la synth\u00e8se totale de la jaspine B impliquant la cyclisation carbonylative hautement diast\u00e9r\u00e9os\u00e9lective catalys\u00e9e par Pd(II) dans la pr\u00e9paration d&rsquo;interm\u00e9diaires cruciaux. De nouvelles conditions pour cette transformation ont \u00e9t\u00e9 d\u00e9velopp\u00e9es et impliquaient le <span class=\"html-italic\">p<\/span>BQ\/LiCl comme syst\u00e8me de r\u00e9oxydation et le Fe(CO)<sub>5<\/sub> comme source in situ de quantit\u00e9 st\u0153chiom\u00e9trique de monoxyde de carbone (1,5 \u00e9quivalent molaire). De plus, nous avons d\u00e9montr\u00e9 l&rsquo;utilisation d&rsquo;un r\u00e9acteur \u00e0 flux adoptant les conditions propos\u00e9es pour la pr\u00e9paration \u00e0 grande \u00e9chelle de lactones cl\u00e9s.<\/div>\n<p>&nbsp;<\/p>\n<div class=\"art-keywords in-tab hypothesis_container\"><em>Mots-cl\u00e9s\u00a0: <\/em> Jaspine B\u00a0; <a href=\"https:\/\/georganics.sk\/fr\/flow-chemistry\/\" target=\"_blank\" rel=\"noopener\">chimie des flux<\/a>; <a href=\"https:\/\/georganics.sk\/fr\/special-offers\/palladium-catalysts\/\" target=\"_blank\" rel=\"noopener\">catalyse au palladium<\/a>; cyclisation; carbonylation<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Ce travail d\u00e9crit la synth\u00e8se totale de la jaspine B impliquant la cyclisation carbonylative hautement diast\u00e9r\u00e9os\u00e9lective catalys\u00e9e par Pd(II) dans la pr\u00e9paration d&rsquo;interm\u00e9diaires cruciaux. De nouvelles conditions pour cette transformation ont \u00e9t\u00e9 d\u00e9velopp\u00e9es et impliquaient le pBQ\/LiCl comme syst\u00e8me de r\u00e9oxydation et le Fe(CO)5 comme source in situ de quantit\u00e9 st\u0153chiom\u00e9trique de monoxyde de carbone [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":18920,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-randpost.php","meta":{"_acf_changed":false,"footnotes":""},"folder":[],"class_list":["post-33842","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Flow Pd(II)-Catalysed Carbonylative Cyclisation in the Total Synthesis of Jaspine B - Georganics<\/title>\n<meta name=\"description\" content=\"Explorer la cyclisation carbonylative catalys\u00e9e par Pd(II) dans la synth\u00e8se de la jaspine B, en se concentrant sur la diast\u00e9r\u00e9os\u00e9lectivit\u00e9.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/georganics.sk\/fr\/research\/flow-pdii-catalysed-carbonylative-cyclisation-in-the-total-synthesis-of-jaspine-b\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Flow Pd(II)-Catalysed Carbonylative Cyclisation in the Total Synthesis of Jaspine B\" \/>\n<meta property=\"og:description\" content=\"Explorer la cyclisation carbonylative catalys\u00e9e par Pd(II) dans la synth\u00e8se de la jaspine B, en se concentrant sur la diast\u00e9r\u00e9os\u00e9lectivit\u00e9.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/georganics.sk\/fr\/research\/flow-pdii-catalysed-carbonylative-cyclisation-in-the-total-synthesis-of-jaspine-b\/\" \/>\n<meta property=\"og:site_name\" content=\"Georganics\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-01T14:03:20+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/georganics.sk\\\/fr\\\/research\\\/flow-pdii-catalysed-carbonylative-cyclisation-in-the-total-synthesis-of-jaspine-b\\\/\",\"url\":\"https:\\\/\\\/georganics.sk\\\/fr\\\/research\\\/flow-pdii-catalysed-carbonylative-cyclisation-in-the-total-synthesis-of-jaspine-b\\\/\",\"name\":\"Flow Pd(II)-Catalysed Carbonylative Cyclisation in the Total Synthesis of Jaspine B - 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